Biginelli Synthesis and Theoritical Study of Dihydropyrimidinones
نویسندگان
چکیده مقاله:
An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.
منابع مشابه
Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds
An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.
متن کاملBiginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds
An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green prot...
متن کاملOne-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation
Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thio...
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A one-pot three-component synthesis of dihydropyrimidinones via a molecular iodine-catalyzed tandem reaction of simple readily available mono-substituted urea, alkylaldehyde, and arylaldehyde has been developed. The reaction proceeds with high chemo- and regioselectivity to give highly diverse dihydropyrimidinones in reasonable yields under mild reaction conditions. Moreover, the first catalyti...
متن کاملChemo-/regioselective synthesis of 6-unsubstituted dihydropyrimidinones, 1,3-thiazines and chromones via novel variants of Biginelli reaction.
A novel and facile cascade Biginelli-like assembly employing enaminone, aldehyde and urea/thiourea has been developed, which provides a highly chemo- and regioselective synthesis of new dihydropyrimidinones, 1,3-thiazines and chromones by altering particular functional groups in the reactants.
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عنوان ژورنال
دوره 6 شماره 1
صفحات 50- 55
تاریخ انتشار 2016-06-01
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